<<
>>

(NGF)

(. nerve growth factor, NGF) . - 1986 , .

() . , . - , NGF TrkA ( ) LNGFR (. Low affinity nerve growth factor receptor, .. NGF), (Huang, 2003). NGF, , , LNGFR (Ibanez, 2002).

229 , ( 4). 110-229 . 110-229 .

. 4.

1 - 6 1
7 - 109
110 - 229


, , : GEFSV, 119-123 NSYCTTT, 186-192. . 17 .

. 17. . , .


. ( 5).

5. . , (GEFSV, 119-123 NSYCTTT, 186-192),

: 131 - 161, 165-190, 192-214 8 - , 124-189; 167-217; 177-219 PDB (1WWW), -
(3D) : 129-131, 162-164 : 115-127 :117-123,

178-181,185188,195-197,219224; : 111115, 119-123,128130,161-163

125, 134, 139, 164, 178, 202, 204
(10) PS00248; : 183192 - GEFSV NSYCTTT 50 134,139,164
() : + 129131,162-164: -: 129, 163166 : 195, 199-202, 208-213 - - (): 1. 192214; 2. 131-161


. , - , . , GEFSV (119-123) , NSYCTTT, 186-192 , (Petock, 2003; Tobi, 2007). , NSYCTTT : [GSRE]-C-[KRL]- G-[LIVT]-[DE]-X(3)-[YW]-X-S-X-C ( PS00248 PROSITE) 176 189 .

, (Wiesmann, 1999), , GEFSV (119-123) , . , , GEFSV - (Colangelo, 2008; Bradshaw, 1994). , GEFSV (119-123) NSYCTTT (186-192) , , , , GEFSV. . 18.

, , . , - TrkA, . , : PI3K/Akt/GSK-3 ( -


8) Ras/Raf-1 /MEK/ERK ( 3, . 19). , , . , TrkA PI3K, Ras . .


. 19. .


1

. 20. - .


() PI3K/Akt/GSK-3 Ras/Raf-1/MEK/ERK, . (.. , . 20) , , , CREB (. cAMP Response Element-Binding, .. -- ʻ), , , (. 21). . , , , CREB, .


, .

, . , - - (Garmachuk, 2009) - / - (, 2008). , - ( Fas, FasL, p

<< | >>
: . ., . .. - 61 . - .: , 2012- 747 .. 2012

(NGF):

  1. ...
  2. ,
  3. 12) , .
  4. .
- -
- - - - - - - - - - - - - -