.., .., .. . 1992; 9-10: 71-74. .. CD45 : - .
.... . . . , 1999. .., .., -

.. . ( ): . ., 1988. .., .., .., .. , . .: , 2001. .., .., - .., A4.fi. /3-: . , . , - . 2005; 7(4): 393-402. .., .., ..

. - . , . 1994; 57(6): 44-48. .., .., - .. - in vitro. . , . 2001; 64(4): 68-72. .. /S- . , . , . 2005; 7(1): 92-96. .., .., .. . : , 2007: 69-76. .. . .: , 2005. .. : . .: , 2006. .., .. . Consilium Medicum 2007; 9(1): 12-51. Antunez ., Fernandez ., Blanca-Lopez N. et al. IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response.

Immediate hypersensitivity reactions to penicillins and other betalactams. Curr. Pharm. Des. 2006; 12: 3327-3333. Bianchi C., Schiuma A., Stringa O. et al. Cutaneous reaction by ampicillin, do present themselves with a greater frequency than other penicillin derivates and in general rule they are of the urticaria or exanthematous type. Med. Cutan. Ibero Lat. Am. 1983; 11: 113-116. Blanca A4., Cornejo-Garcia J.A., Torres M.J., Mayorga C. Specificities of cell reactions to drugs. The penicillin model. Toxicology 2005; 209: 181-184. Brooks B.M., Hart C.A., Coleman J.W. Differential effects of beta-lactams on human IFN-gamma activity. J. Antimicrob. Che- mother. 2005; 56: 1122-1125. Brooks B.M., Flanagan B.F., Thomas A.L., Coleman J.W. Penicillin conjugates to interferon-gamma and reduces its activity: a novel drug-cytokine interaction. Biochem. Biophys. Res. Commun. 2001; 288: 1175-1181. Calvo J., Martinez-Martinez L. Antimicrobial mechanisms of action. Enferm. Infecc. Microbiol. Clin. 2009; 27: 44-52. Casal J., Gimenez M.J., Aguilar L. et al. Beta-lactam activity against resistant pneumococcal strains is enhanced by the immune

system. J. Antimicrob. Chemother. 2002; 50: 83-86. Chen D., Falsetti S.C., Frezza M. ef al. Anti-tumor activity of N-thiolated beta-lactam antibiotics. Cancer Lett. 2008; 268: 63-69. Cui W., Lei M.G., Silverstein R., Morrison C. Differential modulation of the induction of inflammatory mediators by antibiotics in mouse macrophages in response to viable Gram-positive and Gram-negative bacteria. J. Endotoxin. Res. 2003; 9: 225-236. Dabrowski M.P., Stankiewicz W. Desirable and undesirable immunotropic effects of antibiotics: immunomodulating properties of cefaclor. J. Chemother. 2001; 13: 615620. Dufour V., Millon L., Faucher J.F. et al. Effects of a short-course of amoxicillin/clavu- lanic acid on systemic and mucosal immunity in healthy adult humans. Int. Immunophar- macol. 2005; 5: 917-928. Dundaroz R., Ulucan H., Denli M. et al.

Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever.

Pediatr. Int. 2001; 43: 276-280. Fallon R.M., Kuti J.L., Doern G.V. et al. Pharmacodynamic target attainment of oral beta-lactams for the empiric treatment of acute otitis media in children. Paediatr. Drugs 2008; 10: 329-335. Frezza M., Garay J., ChenD. etal. Induction of tumor cell apoptosis by a novel class of N- thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring. Int. J. Mol. Med. 2008; 21: 689-695. Giwerecman B., Rasmussen T.W., Cionfu O. Antibodies against chromosomal beta-lactase. Int. J. Antimicrob. Agents Chemother. 1994; 38: 2306-2310. Greer L.G., Roberts S.W., Sheffield J.S. et

al. Ampicillin resistance and outcome differences in acute antepartum pyelonephritis. Infect. Dis. Obstet. Gynecol. 2008: CD 891426. Gumbo T. Integrating pharmacokinetics, pharmacodynamics and pharmacogenom- ics to predict outcomes in antibacterial therapy. Curr. Opin. Drug Discov. Devel. 2008; 11: 32-42. Horton H., Weston S.D., Hewitt C.R. Allergy to antibiotics: T-cell recognition of amoxicillin is HLA-DR restricted and does not require antigen processing. Allergy 1998; 53: 83-88. Jacobs M.R. Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters. Clin. Microbiol. Infect. 2001; 7: 589-596. Jansisyanont P., Sessirisombat S., Sastravaha P., Bamroong P. Antibiotic prophylaxis for orthognathic surgery: a prospective, comparative, randomized study between amox- icillin-clavulanic acid and penicillin. J. Med. Assoc. Thai. 2008; 91: 1726-1731. Kadota J., Mizunoe S., Kishi K. et al. Antibiotic-induced apoptosis in human activated peripheral lymphocytes. Int. J. Antimicrob. Agents 2005; 25: 216-220. Kerdine S., Pallardy M., Lamanefre S. et al. Interleukin-10 and interleukin-4 have similar effects on hapten-specific primary antibody responses to penicillin in vivo. Eur. J. Immunol. 1996; 26: 2890-2894. Kim N., Park S.H., Seo G.S. etal. Lafutidine versus lansoprazole in combination with clarithromycin and amoxicillin for one versus two weeks for Helicobacter pylori eradication in Korea. Helicobacter 2008; 13: 542-549. Koponen M., Pichler W.J., de Week A.L. T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets. J. Allergy Clin. Immunol. 1986; 78: 645-652. Kazi A., Hill R., Long T.E. et al. Novel N-thiolated beta-lactam antibiotics selectively induce apoptosis in human tumor and transformed, but not normal or nontransformed. Biochem. Pharmacol. 2004; 67: 365-374. Kenny M.T., Balistreri F.J., Torney H.L. beta-Lactam antibiotic modulation of murine neutrophil cytokinesis. Immunopharmacol Immunotoxicol. 1992; 14: 797-811. Knapp T., Hare E., Feng L. et al. Detection of beta-lactamase reporter gene expression by flow cytometry. Cytometry A 2003; 51: 68-78. Labro M.T. Interference of Antibacterial Agents with Phagocyte Functions: Immu- nomodulation or Immuno-Fairy Tales? Clin. Microbiol. Rev. 2000; 13: 615-650.

Lebrec H., Bachot N., Gaspard I. et al.

Mechanisms of drug-induced allergic contact dermatitis. Cell Biol. Toxicol. 1999; 15: 57-62. Lebrec H., Kerdine S., Gaspard /., Pallardy

M. Th(l)/Th(2) responses to drugs. Toxicology 2001; 158: 25-29. Lee M.R., Sfahl S.S., Gellman S.H. Synthesis of beta-lactams bearing functionalized side chains from a readily available precursor. Org. Lett. 2008; 10: 5317-5319. Limeres J., Sanroman J.F., Tomas /., Diz P. Patients perception of recovery after third molar surgery following postoperative treatment with moxifloxacin versus amoxicillin and clavulanic acid: a randomized, double-blind, controlled study. J. Oral Max- illofac. Surg. 2009; 67: 286-291. LotzS.,SfarkeA., Ziemann C. etal. Beta-lactam antibiotic-induced release of lipoteicho- ic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes. Ann. Clin. Microbiol. Antimicrob. 2006; 27: 5-15. Luque /., Leyva L., lose Torres M. efal. In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001; 56: 611-618. MacGowan A.P., Bowker K.E. Continuous infusion of beta-lactam antibiotics. Clin. Pharmacokinet. 1998; 35: 391-402. Mallmann P., Bruhl P., Dagrosa E.E., Reeves A. Effect of cefodizime on parameters of cell-mediated immunity in vitro. Arzneimit- telforschung. 1992; 42: 567-570. Mandell L.A., AfnanM. Mechanisms of interaction among subinhibitory concentrations of antibiotics, human polymorphonuclear neutrophils, and gram-negative bacilli. Antimicrob. Agents Chemother. 1991; 35: 1291-1297. Melzer N., Meufh S.G., Torres-Salazar D. ef al. A beta-lactam antibiotic dampens excito- toxic inflammatory CNS damage in a mouse model of multiple sclerosis. PLoS ONE 2008; 3: 3149. Moore L.J., Gilbey A.M., Dowson C.G. ef

al. Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-

lactam antibiotics. J. Antimicrob. Chemother. 2007; 59: 35-42. Moore L.J., Pridmore A.C., Lee M.E., Read R.C. Induction of pro-inflammatory cytokine release by human macrophages during exposure of Streptococcus pneumoniae to penicillin is influenced by minimum inhibitory concentration ratio. Int. J. Antimicrob. Agents 2005; 26: 188-196. Ortega E., de Pablo At.A., Gaforio J.J. et al. Modification of acquired immunity in BALB/c mice by aztreonam. Int. J. Antimicrob. Agents 2000; 15: 193-199. Ortega E., de Pablo M.A., Gallego A.At. et al. Modification of natural immunity in mice by imipenem/cilastatin. J. Antibiot. (Tokyo) 1997; 50: 502-508. Padial A., Antunez C., Blanca-Lopez N. et al.

Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin. Exp. Allergy 2008; 38: 822828. Padovan E., von Greyerz S., Pichler W.J., Weltzien H.U. Links Antigen-dependent and -independent IFN-gamma modulation by penicillins. J. Immunol. 1999; 162: 1171 1177. Palomo C., Aizpurua J.M., Ganboa /., Oiar- bide At. From beta-lactams to alpha- and beta-amino acid derived peptides. Amino Acids 1999; 16: 321-343. Prescott W.A. Jr., Kusmierski K.A. Clinical importance of carbapenem hypersensitivity in patients with self-reported and documented penicillin allergy. Pharmacotherapy 2007; 27: 137-142. Rahman M.U., Mazumder A. The immunomodulatory effects of gentamicin, imipen- em, piperacillin and amphotericin on LAK effector function in vitro. FEMS Immunol. Med. Microbiol. 2001; 30: 249-252. Roberts J. A., Roberts M.S., Robertson T.A. et al. Piperacillin penetration into tissue of critically ill patients with sepsisbolus versus continuous administration? Crit. Care Med. 2009; 37: 926-933. Rodriguez A.B., Barriga C., De la Puente M.

Mechanisms of action involved in the chemoattractant activity of three beta-lactam-


ic antibiotics upon human neutrophils. Bio- chem. Pharmacol. 1991; 41: 931-936. Rodriguez-Pena R., Lopez S., Mayorga C. et al. Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams. J. Allergy Clin. Immunol. 2006; 118: 949-956. Romano A., Bousquet-Rouanet L., Viola M. ef al. Benzylpenicillin skin testing is still important in diagnosing immediate hypersensitivity reactions to penicillins. Allergy 2009; 64: 249-253. Roszkowski W., H.L., Roszkowski K. et al.

Antibiotics and immunomodulation: effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin. Med. Microbiol. Immunol. 1985; 173: 279-289. Rubin B.K., Tamaoki J. (eds.) Antibiotics as anti-inflammatory and immunomodulatory agents. Basel: Birk Verlag, 2004. Schuster K.M., Wilson D., Schulman C.l. et al. Continuous-Infusion Oxacillin for the Treatment of Burn Wound Cellulitis. Surg. Infect. (Larchmt.) 2009; 10: 41-45. Schutz P., StinnerB., HattelM., Celik I. Dependence of positive effects of granulocyte colony-stimulating factor on the antibiotic regimen: evaluation in rats with polymicrobial peritonitis. World J. Surg. 2004; 28: 834-844. Singh N., Yu V.L., Mieles L.A., Wegener M.M. Beta-Lactam antibiotic-induced leukopenia in severe hepatic dysfunction: risk factors and implications for dosing in patients with liver disease. Am J Med. 1993; 94: 251-256. Taylor S.C., Shacks S.J., Qu Z., Bryant P.

Combined effects of in vitro penicillin and sickle cell disease sera on normal lymphocyte functions. J. Natl. Med. Assoc. 2002; 94: 678-685. Torfoss D., Hoiby E.A., Holte H., Kvaloy S.

Penicillin and aminoglycoside in febrile neutropenia. Tidsskr. Nor. Laegeforen. 2008; 128: 2738-2740. van Langevelde P., Ravensbergen £., Grashoff P. et al. Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes. Antimicrob. Agents Chemother. 1999; 43: 2984-2989. Weltzien H.U., Padovan E. Molecular features of penicillin allergy. J. Invest. Dermatol. 1998; 110: 203-206. Young /VI., Plosker G.L. Piperacillin/tazo- bactam: a pharmacoeconomic review of its use in moderate to severe bacterial infections. Pharmacoeconomics 2001; 19: 1135 1175.

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